The Israel Air Force attacked Syrian army and Hezbollah targets in the area around Qalamoun in Syria overnight Saturday, Israel Radio reported citing Syrian forces.
The attack killed and wounded Hezbollah fighters in the area close to the Lebanese border, The Jerusalem Post quoted reported quoting Lebanese media outlet Almustaqbal.
Last week, Israel reportedly attacked targets in the same area of Syria.
In that attack, the sources claimed that 13 Syrian troops and Hezbollah fighters were killed and dozens were wounded, including four seriously.
Qalamoun has been a major transit point for Hezbollah fighters and other logistical equipment to and from Syria.
In October, Syrian media reported Israeli fighter jets attacked numerous Hezbollah targets in the South of Syria including a weapons convoy destined for Hezbollah fighters.
Israel has reportedly struck Hezbollah in Syria several times over the past year, although the military regularly declines to comment on foreign media reports.